I think that it would be beneficial to go over the previous research as it pertains to this project. The most influential paper can be found here: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031302
However, that paper is very technical and difficult to understand, so I'll sum it up for you now. Basically, Tauopathy is a fancy word for tangles of Tau protein in your brain that cause bad things to happened and brain cells to die. This paper begins by telling us that tauopathy starts in a bit of the brain that's in the middle. The point of this experiment was to determine whether the tauopathy spreads along synaptically connected pathways, which means that their testing to see it the bad stuff spreads through touching other things or if it's caused by something else. They used a "transgenic mouse model" in order to track the tauopathy through the mouse brain throughout the course of their lives to see if the different brain pictures matched those of an equivalent human brain. By measuring the progress of the disease in mice brains, they could extrapolate the same path the disease would take in human brains. They wanted to know whether the tau was transferred in between synapses or if it developed independently. If the disease was transferred via synapses, then it was possible that the Tau might be contained to a certain region of the brain, not being allowed to spread farther and cause further damage to the brain. They tracked the progression of the tau by detecting it with MC1 (monoclonal antibody) in mouse brains ranging in age from 10 months to 22 months. They came to the conclusion that tau did spread trans-synaptically and could possibly contained to a specific part of the brain to prevent further damage.